The appearance of a mysterious little boy interrupts the quiet, predictable life shared by an artist with autism and his caring older brother.

A community is shocked when the bodies of an elderly man and the manager of a home-visit nursing centre are found. The passing of 42 elderly patients is connected to Shiba, a caretaker recognised for his affection and dedication.

Masajiro Miyazawa owns and runs a pawn shop for generations. His first son is Kenji and his daughter is Toshi Miyazawa. Kenji is supposed to take over the pawn shop as the first son, but he refuses. Masajiro is soft on his son. Meanwhile, Toshi is smart and wise. She gives advice to her father and her older brother. One day, Toshi gets sick.

Set in the 19th century, "Moeyo Ken" follows the life of Toshizo Hijikata. He was the vice-commander of the Shinsengumi and fought against the Meiji Restoration.