Nurse Lena Simon seems to have found the perfect man in savvy businessman Scotty Sharpe, but when she suspects him of seeing someone else she takes the unusual advice of her best friend Toni and does a voodoo spell on him.

When a giant alien spider escapes from a military lab and rampages across the city of Los Angeles, it is up to one clever exterminator and his security guard sidekick to kill the creature before the entire city is destroyed.